Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis.
Identifieur interne : 000D55 ( Main/Exploration ); précédent : 000D54; suivant : 000D56Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis.
Auteurs : Steven D. Nathan [États-Unis] ; Carlo Albera [Italie] ; Williamson Z. Bradford [États-Unis] ; Ulrich Costabel [Allemagne] ; Ian Glaspole [Australie] ; Marilyn K. Glassberg [États-Unis] ; David R. Kardatzke [États-Unis] ; Monica Daigl [Suisse] ; Klaus-Uwe Kirchgaessler [Suisse] ; Lisa H. Lancaster [États-Unis] ; David J. Lederer [États-Unis] ; Carlos A. Pereira [Brésil] ; Jeffrey J. Swigris [États-Unis] ; Dominique Valeyre [France] ; Paul W. Noble [États-Unis]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2017.
Abstract
In clinical trials of idiopathic pulmonary fibrosis, rates of all-cause mortality are low. Thus prospective mortality trials are logistically very challenging, justifying the use of pooled analyses or meta-analyses. We did pooled analyses and meta-analyses of clinical trials of pirfenidone versus placebo to determine the effect of pirfenidone on mortality outcomes over 120 weeks.
DOI: 10.1016/S2213-2600(16)30326-5
PubMed: 27876247
Affiliations:
- Allemagne, Australie, Brésil, France, Italie, Suisse, États-Unis
- Californie, Colorado, Floride, Piémont, Tennessee, Virginie, État de New York, État de São Paulo, Île-de-France
- Bobigny, São Paulo, Turin
- Université de São Paulo
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Pereira</name><affiliation wicri:level="4"><nlm:affiliation>Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Paulista School of Medicine, Federal University of São Paulo, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Swigris, Jeffrey J" sort="Swigris, Jeffrey J" uniqKey="Swigris J" first="Jeffrey J" last="Swigris">Jeffrey J. Swigris</name><affiliation wicri:level="2"><nlm:affiliation>National Jewish Health, Denver, CO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Jewish Health, Denver, CO</wicri:regionArea><placeName><region type="state">Colorado</region></placeName></affiliation></author><author><name sortKey="Valeyre, Dominique" sort="Valeyre, Dominique" uniqKey="Valeyre D" first="Dominique" last="Valeyre">Dominique Valeyre</name><affiliation wicri:level="3"><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Avicenne Hospital University, Bobigny, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique-Hôpitaux de Paris, Avicenne Hospital University, Bobigny</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Bobigny</settlement></placeName></affiliation></author><author><name sortKey="Noble, Paul W" sort="Noble, Paul W" uniqKey="Noble P" first="Paul W" last="Noble">Paul W. Noble</name><affiliation wicri:level="2"><nlm:affiliation>Cedars Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cedars Sinai Medical Center, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory medicine</title><idno type="eISSN">2213-2619</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In clinical trials of idiopathic pulmonary fibrosis, rates of all-cause mortality are low. Thus prospective mortality trials are logistically very challenging, justifying the use of pooled analyses or meta-analyses. We did pooled analyses and meta-analyses of clinical trials of pirfenidone versus placebo to determine the effect of pirfenidone on mortality outcomes over 120 weeks.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>France</li><li>Italie</li><li>Suisse</li><li>États-Unis</li></country><region><li>Californie</li><li>Colorado</li><li>Floride</li><li>Piémont</li><li>Tennessee</li><li>Virginie</li><li>État de New York</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Bobigny</li><li>São Paulo</li><li>Turin</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Virginie"><name sortKey="Nathan, Steven D" sort="Nathan, Steven D" uniqKey="Nathan S" first="Steven D" last="Nathan">Steven D. Nathan</name></region><name sortKey="Bradford, Williamson Z" sort="Bradford, Williamson Z" uniqKey="Bradford W" first="Williamson Z" last="Bradford">Williamson Z. Bradford</name><name sortKey="Glassberg, Marilyn K" sort="Glassberg, Marilyn K" uniqKey="Glassberg M" first="Marilyn K" last="Glassberg">Marilyn K. Glassberg</name><name sortKey="Kardatzke, David R" sort="Kardatzke, David R" uniqKey="Kardatzke D" first="David R" last="Kardatzke">David R. Kardatzke</name><name sortKey="Lancaster, Lisa H" sort="Lancaster, Lisa H" uniqKey="Lancaster L" first="Lisa H" last="Lancaster">Lisa H. Lancaster</name><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J" last="Lederer">David J. Lederer</name><name sortKey="Noble, Paul W" sort="Noble, Paul W" uniqKey="Noble P" first="Paul W" last="Noble">Paul W. Noble</name><name sortKey="Swigris, Jeffrey J" sort="Swigris, Jeffrey J" uniqKey="Swigris J" first="Jeffrey J" last="Swigris">Jeffrey J. Swigris</name></country><country name="Italie"><region name="Piémont"><name sortKey="Albera, Carlo" sort="Albera, Carlo" uniqKey="Albera C" first="Carlo" last="Albera">Carlo Albera</name></region></country><country name="Allemagne"><noRegion><name sortKey="Costabel, Ulrich" sort="Costabel, Ulrich" uniqKey="Costabel U" first="Ulrich" last="Costabel">Ulrich Costabel</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Glaspole, Ian" sort="Glaspole, Ian" uniqKey="Glaspole I" first="Ian" last="Glaspole">Ian Glaspole</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Daigl, Monica" sort="Daigl, Monica" uniqKey="Daigl M" first="Monica" last="Daigl">Monica Daigl</name></noRegion><name sortKey="Kirchgaessler, Klaus Uwe" sort="Kirchgaessler, Klaus Uwe" uniqKey="Kirchgaessler K" first="Klaus-Uwe" last="Kirchgaessler">Klaus-Uwe Kirchgaessler</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Pereira, Carlos A" sort="Pereira, Carlos A" uniqKey="Pereira C" first="Carlos A" last="Pereira">Carlos A. Pereira</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Valeyre, Dominique" sort="Valeyre, Dominique" uniqKey="Valeyre D" first="Dominique" last="Valeyre">Dominique Valeyre</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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